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Micronucleus formation in mouse bone marrow cells in vivo in response to trans, trans-muconaldehyde

Authors
Journal
Toxicology Letters
0378-4274
Publisher
Elsevier
Publication Date
Volume
121
Issue
3
Identifiers
DOI: 10.1016/s0378-4274(01)00340-x
Keywords
  • Trans
  • Trans-Muconaldehyde
  • Micronucleus
  • Cytotoxicity
  • Mouse Bone Marrow

Abstract

Abstract Benzene is a human leukemogen, and a bone marrow toxin and carcinogen in experimental animals. The reactive intermediates involved in benzene toxicity and their mechanism(s) of action have not been clearly delineated. We have investigated the clastogenic and cytotoxic effects of trans,trans-muconaldehyde (MUC), a reactive ring-opened benzene metabolite, in mouse bone marrow cells in vivo. Micronucleus formation was significantly increased when CD-1 mice were treated ip with MUC at 4 and 6 mg/kg/day for two days. These results suggest that leukemogenesis by benzene may be attributable, in part, to MUC-related clastogenic and cytotoxic effects in the bone marrow cells.

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