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Carp head kidney leukocytes display different patterns of oxygen radical production after stimulation with PAMPs and DAMPs

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Publisher
Pergamon
Publication Date
Keywords
  • Wound Healing And Tissue Regeneration Are Essential Mechanisms To Ensure The Survival And Health Of
  • Despite This
  • Only A Few Studies Have Been Devoted To Study Tissue Regeneration During Wound Healing In Fish
  • Reactive Oxygen Species (Ros)
  • In Particular Hydrogen Peroxide
  • Play An Important Dual Role Both For Promoting Tissue Repair
  • But Also For Eradication Of Pathogens
  • This Study Aims At Dissecting The Contribution Of Pamps (Using β-Glucan) And Damps In The Respirato
  • And Address Their Contribution To Wound Healing Processes
  • Consistent With A Pathogen Eradication Strategy
  • Ros Responses To Pamp Stimulation (β-Glucan) Was Fast
  • Vigorous And Highly Dominated By Production Of Superoxide Anion
  • In Contrast
  • Stimulation With Damps Led To A Slow
  • Subtle But Long-Lasting Production Of Oxygen Radicals Dominated By Hydrogen Peroxide
  • Using An In Vitro Model Of Scratch-Wounded Ccb Fibroblast Cell Cultures And A Novel Photoid Prolifer
  • Stimulation With Low And Continuous Levels Of Hydrogen Peroxide (5μM) Led To A Slight Increase In T
  • In Contrast
  • High Doses Of Hydrogen Peroxide (300μM) Impaired Fibroblast Scratch-Wound Recovery And Caused Cell
  • These Results Elucidate The Capacity Of Hydrogen Peroxide To Influence The Fate Of Tissue Regenerati
  • Direct In Vitro Stimulation With β-Glucans Did Not Impact Fibroblast Scratch-Wound Recovery
  • Which Further Suggests That Interaction With Tissue-Resident Leukocytes Or Other Components Of The F

Abstract

Carp head kidney leukocytes display different patterns of oxygen radical production after stimulation with PAMPs and DAMPs - DTU Orbit (26/04/14) Jiménez, Natalia Ivonne Vera and Michael Engelbrecht Nielsen. "Carp head kidney leukocytes display different patterns of oxygen radical production after stimulation with PAMPs and DAMPs". Molecular Immunology. 2013, 55(3-4). 231-236. Available: 10.1016/j.molimm.2013.01.016

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