Affordable Access

Publisher Website

Mandibular prognathism in Japanese families ascertained through orthognathically treated patients

Authors
Journal
American Journal of Orthodontics and Dentofacial Orthopedics
0889-5406
Publisher
Elsevier
Publication Date
Volume
128
Issue
4
Identifiers
DOI: 10.1016/j.ajodo.2004.09.018
Disciplines
  • Ecology
  • Geography
  • Medicine

Abstract

Introduction: Patients with severe mandibular prognathism frequently require orthognathic surgery to correct skeletal disharmony. Genetic and environmental factors are suggested in the etiology of mandibular prognathism, but the precise contribution of these factors is unknown. Methods: To clarify the impact of genetic factors on mandibular prognathism, we gave a questionnaire to 105 subjects with severe skeletal Class III mandibular prognathism who planned to undergo or had undergone orthognathic surgery. The questionnaire assessed mandibular prognathism in 3 generations of each subject’s family. All answers were confirmed in a careful interview that included differentiation of “maxillary deficiency” and “mandibular excess.” This is the first 3-generation family study of mandibular prognathism in orthognathically treated patients. Results: The average ANB, SNA, and SNB angles in the probands were −3.7°, 80.9°, and 84.6°, respectively. A total of 1480 family members were examined, and 11.2% had mandibular prognathism. Men were slightly more affected than women; 68.6% of families had at least 1 member other than the proband with mandibular prognathism. The affected ratio of first-degree relatives was more than twice that of second-degree relatives (17.5% and 7.6%, respectively). There was no difference in the occurrence between fathers and mothers of probands, and siblings showed a high affected ratio of 25.0%. Falconer’s heritability was calculated as 84.3% in first-degree relatives. Conclusions: A high occurrence of mandibular prognathism was seen in families of orthognathically treated skeletal Class III patients, suggesting a profound genetic influence.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Mandibular prognathism in Japanese families ascert...

on American Journal of Orthodonti... October 2005

[The position and course of mandibular canal throu...

on Shanghai kou qiang yi xue = Sh... April 2008

Genome-wide linkage analysis of mandibular prognat...

on Journal of dental research March 2005

Segregation analysis of mandibular prognathism in...

on The Angle Orthodontist November 2013
More articles like this..