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The effects of prostaglandin f2αon vascular permeability and collagen and non-collagen protein synthesis of preformed chronic carrageenin granuloma in rats

Authors
Journal
Biochemical Pharmacology
0006-2952
Publisher
Elsevier
Publication Date
Volume
26
Issue
21
Identifiers
DOI: 10.1016/0006-2952(77)90015-6
Disciplines
  • Biology

Abstract

Abstract Prostaglandin F 2α (PG F 2α) was administered into the pouch fluid of 7-day-old carrageenin granuloma in rats and the effects of PG F 2α on vascular permeability and collagen and non-collagen protein synthesis of the granuloma were investigated. At a dose of 10 μg of PG F 2α, vascular permeability as measured by the leakage of radioiodinated human serum albumin into the pouch fluid was not inhibited, but at doses of 50, 100 and 250 μg of PG F 2α, vascular permeability was inhibited significantly. The incorporation of [ 3H]proline into collagen hydroxyproline and into non-collagen protein of carrageenin granuloma was also inhibited by local administration of PG F 2α. The mechanism of the effects of PG F 2α is discussed.

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