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A facile synthesis of 3,5-dimethyl-4-hydroxybenzaldehyde via copper-mediated selective oxidation of 2,4,6-trimethylphenol

Authors
Journal
Catalysis Today
0920-5861
Publisher
Elsevier
Publication Date
Volume
131
Identifiers
DOI: 10.1016/j.cattod.2007.10.062
Keywords
  • Oxidation
  • Copper(Ii) Chloride
  • Mesitol
  • 2
  • 6-Dimethyl-4-(Isopropoxymethyl)Phenol
  • 3
  • 5-Dimethyl-4-Hydroxybenzaldehyde

Abstract

Abstract 2,4,6-Trimethylphenol was selectively oxidized to 3,5-dimethyl-4-hydroxybenzaldehyde in very good yields using catalytic or equivalent amounts of CuCl 2 in the presence of K 2CO 3 and H 2O 2 in i-PrOH at 65 °C. The effect of the molar ratios of CuCl 2, K 2CO 3 and H 2O 2 on the yields and product distribution was examined. The oxidation reaction was found to proceed smoothly without the use of additives or ligands which were reported to be necessary.

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