Affordable Access

A CONTRIBUTION TO THE KNOWLEDGE OF THE PATHOLOGY OF FRAGMENTATION AND SEGMENTATION, AND FIBROSIS OF THE MYOCARDIUM

Authors
Journal
Journal of Experimental Medicine
0022-1007
Publisher
The Rockefeller University Press
Publication Date
Keywords
  • Article

Abstract

0409.tif A CONTRIBUTION TO THE KNOWLEDGE OF THE PATHOLOGY OF FRAGMENTATION AND SEGMENTATION, AND FIBROSIS OF THE IV[YOCARDIUM. BY JOHN BRUCE MAoCALLUM. (From the Pathological Laboratory of the Johns Hopkins University and ttospgtal.) PLATES XXI AND XXII. In order to make clear the following description of the minute changes taking place in the heart-muscle cell, it will be well first to describe briefly the appearances met with in normal cardiac muscle. In a previous paper* I have given a detailed description of these, together with an account of the histogenesis of the cardiac muscle cell. HISTOLOGY OF THE MUSCLE OF THE NORMAL HEART. The normal adult heart muscle of the human subject is made up of irregular rhomboidal cells, which are usually considerably branched. Each cell consists of darkly staining columns, which run longitudi- nally and are separated by unstained substance. These columns are commonly spoken of as fibril bundles, and correspond with what v. KSlliker has called "3luskelsi~ulchen." The unstained substance between is generally known as sarcoplasm. Careful observation and certain methods of special staining reveal a definite relation between these two parts of the cell. The fibril bundles are striated like voluntary muscle, showing a narrow disc called Krause's membrane, and a broader disc or Briicke's line of doubly refractive substance between each two narrow striations. Krause's membrane corresponds with the "Zwischenscheibe" of Ge.r- man writers, and Briicke's line is identical with the " Querscheibe." * J. ]3. MacCallum, On the Histology and Histogenesis of the tteart -mus- cle Cell, Anntor~scher Anzeiger, 1897, xiii, 609. 410 Fragme~taHon, Segmentatio~ a~d Fibrosis of Myocardi~m ]n thin sections, especially those stained by Xolossow's method, the Xrause's membranes are seen to belong to the sarcoplasm as well as to the fibril bundles (Plate XXI, Fig. 1). The sarcoplasm is divided into distinct discs by memb

There are no comments yet on this publication. Be the first to share your thoughts.