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B-cell targeting in chronic graft-versus-host disease

Authors
  • Zeiser, Robert1
  • Sarantopoulos, Stefanie2
  • Blazar, Bruce R.3
  • 1 Department of Hematology, Oncology and Stem Cell Transplantation, Faculty of Medicine, Freiburg University, Freiburg, Germany;
  • 2 Division of Hematological Malignancies and Cellular Therapy, Department of Medicine, Duke Cancer Institute, Duke University Medical Center, Durham, NC; and
  • 3 Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN
Type
Published Article
Journal
Blood
Publisher
American Society of Hematology
Publication Date
Mar 29, 2018
Volume
131
Issue
13
Pages
1399–1405
Identifiers
DOI: 10.1182/blood-2017-11-784017
PMID: 29437591
PMCID: PMC6031308
Source
PubMed Central
License
Unknown

Abstract

Over the last decade, our understanding of the pathophysiology of chronic graft-versus-host disease (cGVHD) has improved considerably. In this spotlight, we discuss emerging insights into the pathophysiology of cGVHD with a focus on B cells. First, we summarize supporting evidence derived from mouse and human studies. Next, novel cGVHD therapy approaches that target B cells will be covered to provide treating physicians with an overview of the rationale behind the emerging armamentarium against cGVHD.

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