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In vitrometabolism of testosterone in the rat brain during sexual maturation—III: Studies of the formation of main androstane-diols and androstene-diols

Authors
Journal
Journal of Steroid Biochemistry
0022-4731
Publisher
Elsevier
Publication Date
Volume
6
Issue
8
Identifiers
DOI: 10.1016/0022-4731(75)90114-4

Abstract

Abstract Tissue fragments obtained from hypothalamus, hypophysis, prostate and cerebral cortex of male rats were incubated in the presence of [1,2- 3H]-testosterone. The incubation media were subsequently extracted, and the following compounds: 5α-androstan-3α,17β-diol; 5α-androstan-3β,17β-diol; 5β-androstan-3α, 17β-diol; 5β-androstan-3β, 17β-diol; 4-androsten-3α, 17β-diol; 4-androsten-3β, 17β-diol, were identified and compared with testosterone. The largest amounts of 5α-androstan-3α,17β-diol were produced by the prostate and the hypophysis and of 4-androsten-3α, 17β-diol by the hypothalamus. A peak of hypophyseal 5α-androstan-3α,17β-diol was observed in the 6-week-old rats; this phenomenon could be related to the peak of gonadotropin which has been demonstrated in the serum of rats at this age.

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