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The increased natural killer sensitivity of Epstein-Barr virus (EBV)-superinfected Raji cells is not due to the recognition of serologically determined EBV antigens by the effectors

Authors
Journal
Cellular Immunology
0008-8749
Publisher
Elsevier
Publication Date
Volume
67
Issue
1
Identifiers
DOI: 10.1016/0008-8749(82)90207-6

Abstract

Abstract The NK sensitivity of Raji cells was elevated after superinfection with the P3HR-1 strain of Epstein-Barr virus (EBV). The superinfected cells reacted with EBV antibody-positive sera and this was detectable by ADCC. F(ab′) 2 fragments from the antibody-positive sera blocked the ADCC reaction but did not affect attachment of lymphocytes and natural killing. This indicates that the EBV-determined membrane antigens that serve as targets for the reactivity with the sera are not responsible for the increased NK sensitivity.

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