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A novel synthesis of spiro[(2,2-dimethyl-[1,3]-dioxane)-5,2′-(2′,3′-dihydroindole)] using SRN1 reaction conditions

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
45
Issue
8
Identifiers
DOI: 10.1016/j.tetlet.2003.12.092
Keywords
  • Spiroindolines
  • Cyclization
  • Srn1 Reaction Conditions
  • 1
  • 3-Dioxane
  • Nitronate Anion

Abstract

Abstract A concise synthesis of the spiro[(2,2-dimethyl-[1,3]-dioxane)-5,2′-(2′,3′-dihydroindole)] nucleus from substituted benzyl chlorides and 5-(hydroxymethyl)-2,2-dimethyl-5-nitro-1,3-dioxane 5 as starting materials is reported. The nitro intermediates 6 and 7 were prepared under S RN1 reaction conditions.

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