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Potential Targeting of Siglecs, Mast Cell Inhibitory Receptors, in Interstitial Cystitis

Authors
Journal
International Neurourology Journal
2093-4777
Publisher
Korean Continence Society
Publication Date
Volume
15
Issue
2
Identifiers
DOI: 10.5213/inj.2011.15.2.61
Keywords
  • Review
Disciplines
  • Biology
  • Medicine

Abstract

Mast cell increases and activation are detected in the chronic inflammatory bladder disease interstitial cystitis (IC), and their proinflammatory mediators are felt to contribute to regional pelvic pain and inflammatory pathophysiology. The immunoreceptor tyrosine-based inhibition motif-containing sialic acid-binding immunoglobulin-like lectins (Siglecs) expressed in mast cells could be evaluated as in vivo signaling regulators capable of inhibiting IC-related mast cell activation.

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