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Association between folic acid food fortification and congenital orofacial clefts

Authors
Journal
The Journal of Pediatrics
0022-3476
Publisher
Elsevier
Publication Date
Volume
143
Issue
6
Identifiers
DOI: 10.1067/s0022-3476(03)00495-5

Abstract

Abstract By January 1998, most of Canada's cereal grain products were being fortified with folic acid. Among 336,963 women who underwent antenatal maternal serum screening, the prevalence of orofacial clefts did not change from before (1.15 per 1000) to after (1.21 per 1000) food fortification (prevalence ratio, 1.06; 95% confidence interval, 0.86–1.30).

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