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Lead concentrations in blood, plasma, erythrocytes, and cerebrospinal fluid in amyotrophic lateral sclerosis

Authors
Journal
Journal of the Neurological Sciences
0022-510X
Publisher
Elsevier
Publication Date
Volume
61
Issue
1
Identifiers
DOI: 10.1016/0022-510x(83)90051-5
Keywords
  • Amyotrophic Lateral Sclerosis
  • Cerebrospinal Fluid
  • Lead

Abstract

Abstract The purpose of the investigation was to elucidate the repeatedly discussed relationship between chronic lead intoxication and ALS. The following mean lead concentrations were determined in 9 patients with ALS: 8.65 ± 3,91μ g 100 ml in the blood, 0.97 ± 0.78 μ g 100 ml in the plasma, 19.15 ± 5.0 μ g 100 ml in the erythrocytes, and 0.89 ± 0.44 μ g 100 ml in the cerebrospinal fluid. These values did not differ appreciably from the controls with 7.91 ± 3.83 μ g 100 ml (n = 14) in the blood, 1.13 ± 0.46 μ g 100 ml (n = 10) in the plasma, 18.96 ± 12.63 μ g 100 ml (n = 10) in the erythrocytes, and 0.85 ± 0.91 μ g 100 ml (n = 15) in the cerebrospinal fluid. These findings do not support the assumption of lead poisoning as a pathogenetic factor in ALS.

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