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Synthesis of stereoisomerically pube (E)-1,5-diyn-3-enes and (E)-1-bromo-3-yn-1-enes by diastereoselective palladium-catalyzed cross-coupling reaction of 1-alkynylzinc chlorides with a stereoisomeric mixture of 1,2-dibromoethylene.

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
27
Issue
36
Identifiers
DOI: 10.1016/s0040-4039(00)94272-2

Abstract

Abstract In the stepeospecific palladium-catalyzed cross coupling reaction of 1-alkynylzinc chlorides, (E)-1,2-dibromoethylene reacts preferentially in the presence of (Z)-1,2-dibromoethylene.Products of di- or mono-substitution can be obtained according to the ratio of reagents.

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