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Synthesis of carbon-11 labeled diprenorphine: A radioligand for positron emission tomographic studies of opiate receptors

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
28
Issue
35
Identifiers
DOI: 10.1016/s0040-4039(01)83849-1

Abstract

Abstract Selective alkylation of 3-(O- t -butyldimethylsilyl)-6-(O-desmethyl)-diprenorphine with [ 11C]-methyl iodide followed by desilylation affords [ 11C]-dipronorphine labeled at the 6-methoxy position in 10% yield with a specific activity of 1740 mCi/μmol at the end of a 30 minute synthesis.

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