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Amiloride does not block taste transduction in the mouse (Slc:ICR)

Authors
Journal
Comparative Biochemistry and Physiology Part A Physiology
0300-9629
Publisher
Elsevier
Publication Date
Volume
94
Issue
4
Identifiers
DOI: 10.1016/0300-9629(89)90612-9

Abstract

Abstract 1. 1. The receptor potential of the mouse taste cell was recorded with an intracellular microelectrode while taste stimuli were applied to the tongue surface of the anesthetized mouse. 2. 2. A membrane depolarization accompanied by an increase in membrane resistance was observed after a sucrose stimulus. 3. 3. A sodium-chloride stimulus initiated a membrane depolarization accompanied by a decrease in membrane resistance. 4. 4. Amiloride elicits a depolarization of the membrane and is accompanied by an increase in membrane resistance. 5. 5. Pre-adapting the tongue to amiloride, which is known as a potent sodium channel blocker, did not alter the responses to sodium-chloride and other taste stimuli.

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