Affordable Access

Publisher Website

Effect of 5-HT3receptor antagonist (ondansetron) on functioning human pancreatic carcinoid cells

Authors
Journal
Surgical Oncology
0960-7404
Publisher
Elsevier
Publication Date
Volume
2
Issue
4
Identifiers
DOI: 10.1016/0960-7404(93)90010-v
Keywords
  • Ca2+
  • Camp
  • Carcinoid Cells
  • 5-Hydroxytryptamine
  • Ondansetron
  • Phosphatidylinositol Hydrolysis
Disciplines
  • Biology

Abstract

Abstract 5-Hydroxytryptamine (5-HT) is a mitogen for selected cell types. We have reported that 5-HT is an autocrine growth factor for functioning human pancreatic carcinoid (BON) cells; autocrine growth effect is transmitted by 5-HT 1A but not 5-HT 1C 2 receptors, activation of which decreases cyclic AMP production through a pertussis toxin-sensitive inhibitory GTP-binding protein. In this study, the effect of 5-HT 3 receptor antagonist, ondansetron, on BON was examined. Ondansetron did not affect growth of BON cells and also affected neither stimulation of phosphatidylinositol hydrolysis or inhibition of cyclic AMP production evoked by 5-HT in BON cells. Ondansetron, however, inhibited mobilization of intracellular calcium evoked by 5-HT. Present findings suggest that BON cells possess 5-HT 3 receptors, but their roles in pancreatic carcinoid cells are still unknown.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Efficacy of 5HT3receptor antagonists

on European Neuropsychopharmacolo... Jan 01, 1993

Effects of the 5-HT3receptor antagonist ondansetro...

on European Journal of Pharmacolo... Jan 01, 1999

The effects of ondansetron, a 5-HT3receptor antago...

on Pharmacology Biochemistry and... Jan 01, 1990
More articles like this..