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Can cardiac MRI be the 'crystal ball' for risk stratification in dilated cardiomyopathy? The impact of an LV mid-myocardial stripe on LVAD and transplantation risk

Authors
Journal
Journal of Cardiovascular Magnetic Resonance
1097-6647
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
13
Identifiers
DOI: 10.1186/1532-429x-13-s1-o102
Keywords
  • Oral Presentation
Disciplines
  • Medicine

Abstract

Can cardiac MRI be the 'crystal ball' for risk stratification in dilated cardiomyopathy? The impact of an LV mid-myocardial stripe on LVAD and transplantation risk ORAL PRESENTATION Open Access Can cardiac MRI be the ‘crystal ball’ for risk stratification in dilated cardiomyopathy? The impact of an LV mid-myocardial stripe on LVAD and transplantation risk Jose Venero1*, Srinivas Murali1, Mark Doyle1, Vikas K Rathi2, Saundra B Grant1, June A Yamrozik1, Ronald B Williams1, Diane Vido1, Geetha Rayarao1, Raymond Benza1, George Sokos1, David Dean1, Robert WW Biederman1 From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011 Introduction Patients with newly diagnosed dilated cardiomyopathy and advanced heart failure have a very high morbidity and mortality with an unpredictable clinical course. We inves- tigated the role of CMR via LGE in this cohort of patients. Purpose Hypothesis Utilizing cardiovascular MRI (CMR), via the late gadolinium enhancement (LGE), we assessed the prog- nostic value in primary dilated cardiomyopathy(DCM). Methods Over 39 consecutive months, 51 cardiomyopathy patients were referred for standard 3D CMR(1·5T,GE) to interrogate the LV pattern, distribution and extent of DHE (MultiHance, Princeton, NJ). Inclusion criteria were met in 21 patients. DCM were categorized into: 1) +midwall Stripe 2)-Stripe groups. Major adverse clini- cal events (MACE), mortality, need for LV assist device (LVAD), and urgent cardiac transplantation (Tx), were evaluated over the ensuing 6 and 12 months. Results All patients were alive at 12 months while 11/21(52%) demonstrated a +Stripe. There were no differences between groups for demographics, baseline LVEF, LV end-diastolic diameter, NYHA class or hemodynamics. The group with +Stripe categorization strongly predicted the need for LVAD and/or urgent Tx surgery over the ensuing 6 (or 12) months (p<0.005). Specifi- cally, 7/11(74%) +Stripe patients required urgent Tx by 6 months, while no patients in t

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