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Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic:Example: Ethyl carbamate (CAS 51-79-6)

Authors
Journal
Food and Chemical Toxicology
0278-6915
Publisher
Elsevier
Publication Date
Volume
48
Identifiers
DOI: 10.1016/j.fct.2009.10.032
Keywords
  • Ethyl Carbamate
  • Margin Of Exposure
  • Moe

Abstract

Abstract Ethyl carbamate is mutagenic and produces DNA-adducts in vivo, and is carcinogenic in rodent bioassays. Dose-response modelling of the data for alveolar and bronchiolar adenoma or carcinoma in male and female mice combined gave a BMDL 10 of 0.25 mg/kg-bw/day. The dietary exposure from consumption of foods and non-alcoholic beverage was estimated to be 1 μg/person/day (15 ng/kg-bw/day), while the exposure of a high-percentile consumer of alcoholic beverages was estimated to be 5 μg/person per day (80 ng/kg-bw/day). The corresponding calculated MOEs were 16600 and 3125, respectively.

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