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Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition

Authors
  • Inclan-Rico, Juan M.1, 1
  • Ponessa, John J.1, 1
  • Valero-Pacheco, Nuriban1, 1
  • Hernandez, Christina M.1, 1
  • Sy, Chandler B.1, 1
  • Lemenze, Alexander D.1
  • Beaulieu, Aimee M.1, 1
  • Siracusa, Mark C.1, 1
  • 1 New Jersey Medical School, Rutgers—The State University of New Jersey, Newark, NJ, USA , Newark (United States)
Type
Published Article
Journal
Nature Immunology
Publisher
Springer Nature
Publication Date
Aug 17, 2020
Volume
21
Issue
10
Pages
1181–1193
Identifiers
DOI: 10.1038/s41590-020-0753-y
Source
Springer Nature
License
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Abstract

Siracusa and colleagues reveal a regulatory role for basophils in the context of anti-helminth immunity and identify the neuropeptide neuromedin B as a potent inhibitor of type 2 inflammation.

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