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Basophilic differentiation of chronic myelogenous leukaemia cells in vitro.

Authors
  • Miyoshi, I
  • Uchida, H
  • Tsubota, T
  • Kubonish, I
  • Hiraki, S
  • Kitajima, K
Type
Published Article
Journal
Scandinavian journal of haematology
Publication Date
Oct 01, 1977
Volume
19
Issue
4
Pages
321–326
Identifiers
PMID: 270207
Source
Medline
License
Unknown

Abstract

Peripheral leucocytes from 10 patients with chronic myelogenous leukaemia (CML) were cultured in liquid medium and observed morphologically for 6 to 10 weeks. All cultures showed in increased proportion of mature basophilis at about 3 weeks and most cultures consisted predominantly of mature basophilis at about 5 weeks. The results indicate preferential basophilic differentiation of CML leucocytes in vitro and are consistent with basophilia frequently observed in CML patients.

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