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[Basic studies on optimal intra-arterial infusion rate of cisplatin].

Authors
  • Kishimoto, S
  • Fukushima, S
  • Hayashi, Y
  • Nakano, M
  • Miyazaki, K
  • Okamura, H
Type
Published Article
Journal
Gan to kagaku ryoho. Cancer & chemotherapy
Publication Date
Aug 01, 1989
Volume
16
Issue
8 Pt 2
Pages
2788–2791
Identifiers
PMID: 2782889
Source
Medline
License
Unknown

Abstract

The relationship between platinum concentration in tissues, free CDDP concentration in plasma and infusion rate was investigated in order to determine the optimal intra-arterial infusion rate of CDDP for chemotherapy of cervical carcinoma. Platinum concentrations in uterus were in the same level in the intravenous infusion groups independent of the infusion rate. In the intra-arterial infusion groups, platinum concentrations in the uterus increased as the infusion rate decreased from 24 to 0.8 mg/hr, although Cmax and AUC were decreased. Platinum concentrations in the ovary supplied by another artery were not influenced by the intra-arterial infusion rate. It is suggested that uptake of CDDP in the targeted tissues can be increased by control of intra-arterial infusion rate.

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