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Basic and clinical research progress in acute lung injury/acute respiratory distress syndrome

Authors
  • Wang, Tong
Type
Published Article
Journal
Infection International
Publisher
Sciendo
Publication Date
Jun 29, 2018
Volume
7
Issue
2
Pages
38–43
Identifiers
DOI: 10.2478/ii-2018-0017
Source
De Gruyter
Keywords
License
Green

Abstract

Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an acute progressive respiratory failure caused by severe infection, trauma, shock, poisoning, inhaled harmful gas, acute pancreatitis, and pathological obstetrics. ALI and ARDS demonstrate similar pathophysiological changes. The severe stage of ALI is defined as ARDS. At present, a significant progress has been achieved in the study of the pathogenesis and pathophysiology of ALI/ARDS. Whether or not ALI/ARDS patients can recover depends on the degree of lung injury, extra-pulmonary organ damage, original primary disease of a patient, and adequacy in supportive care. Conservative infusion strategies and protective lung ventilation reduce ARDS disability and mortality. In this study, the pathogenesis of ALI/ARDS, lung injury, molecular mechanisms of lung repair, and conservative infusion strategies and pulmonary protective ventilation are reviewed comprehensively.

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