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Baseline Susceptibility to Pyrethroid and Organophosphate Insecticides in Two Old World Sand Fly Species (Diptera: Psychodidae).

Authors
  • Li, Andrew Y
  • Perez de Leon, Adalberto A
  • Linthicum, Kenneth J
  • Britch, Seth C
  • Bast, Joshua D
  • Debboun, Mustapha
Type
Published Article
Journal
U.S. Army Medical Department journal
Publication Date
Jan 01, 2015
Pages
3–9
Identifiers
PMID: 26276940
Source
Medline
License
Unknown

Abstract

Phlebotomine sand flies are blood-feeding insects that transmit Leishmania parasites that cause various forms of cutaneous and visceral leishmaniasis and sand fly fever viruses (Phlebovirus; Bunyaviridae) in humans. Sand flies pose a significant threat to US military personnel deployed to Leishmania-endemic and sand fly fever endemic regions which include Europe, the Mediterranean basin, Middle East, Central Asia, Southwest Asia, and Africa. A research project supported by the Department of Defense Deployed Warfighter Protection Program was initiated to evaluate the susceptibility of 2 Old World sand fly species, Phlebotomus papatasi and P duboscqi, to a number of commonly used pyrethroid and organophosphate insecticides. A new glass vial bioassay technique based on the CDC bottle assay was developed for this study. The exposure time-mortality relationship at a given insecticide concentration was determined for each insecticide, and their relative toxicity against the 2 sand fly species was ranked based on bioassay results. This study validated the new bioassay technique and also generated baseline insecticide susceptibility data to inform future insecticide resistance monitoring work.

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