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Baseline SD-OCT characteristics of diabetic macular oedema patterns can predict morphological features and timing of recurrence in patients treated with dexamethasone intravitreal implants

Authors
  • Eandi, Chiara M.1, 2, 3
  • De Geronimo, Daniele4
  • Giannini, Daniela4
  • Polito, Maria Sole1
  • Tosi, Gian Marco5
  • Neri, Giovanni5
  • Le Mer, Yannick3
  • Varano, Monica4
  • Parravano, Mariacristina4
  • 1 University of Torino,
  • 2 University of Lausanne,
  • 3 Department of Ophthalmology, Fondation Ophtalmologique A. De Rothschild, Paris, France
  • 4 IRCCS - Fondazione Bietti,
  • 5 University of Siena,
Type
Published Article
Journal
Acta Diabetologica
Publisher
Springer Milan
Publication Date
Feb 29, 2020
Volume
57
Issue
7
Pages
867–874
Identifiers
DOI: 10.1007/s00592-020-01504-w
PMID: 32114643
PMCID: PMC7311372
Source
PubMed Central
Keywords
License
Unknown

Abstract

Aims To evaluate the timing and spectral-domain optical coherence tomography (SD-OCT) features of diabetic macular oedema (DME) recurrence according to baseline OCT patterns in patients treated with dexamethasone implant (DEX-I). Methods This is a retrospective observational study (72 eyes/65 patients). Best-corrected visual acuity, timing of DME recurrence, and SD-OCT pattern [intraretinal cysts (IRC), IRC plus subretinal fluid (mixed), external limiting membrane (ELM), ellipsoid (IS/OS) layer integrity] were assessed at baseline and monthly until first DME recurrence. Results Forty-two (58.3%) and 30 (41.6%) DME eyes had an IRC and mixed DME pattern at baseline, respectively. Twenty-four out of thirty mixed eyes (80%) relapsed without subretinal fluid. At baseline, mixed eyes showed similar changes in ELM and IS/OS (60 and 76.6% of eyes, respectively) versus IRC eyes (42.8 and 80.9% of eyes). After DME recurrence, more mixed eyes at baseline showed ELM and IS/OS changes (63.3 and 86.6%) than IRC eyes (50 and 76.2%). 33.3% of mixed eyes had DME recurrence at ≥ 6 months from first DEX-I implant versus 19% of IRC eyes. Conclusions Mixed DME eyes were treated with DEX-I relapse later and more frequently without subretinal fluid than IRC eyes. SD-OCT characteristics of different DME patterns at baseline can predict morphological features and timing of DME recurrence.

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