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Baseline Lower Urinary Tract Symptoms in Patients Enrolled in LURN: A Prospective, Observational Cohort Study.

  • Cameron, Anne P1
  • Lewicky-Gaupp, Christina2
  • Smith, Abigail R3
  • Helfand, Brian T4
  • Gore, John L5
  • Clemens, J Quentin6
  • Yang, Claire C5
  • Siddiqui, Nazema Y7
  • Lai, H Henry8
  • Griffith, James W2
  • Andreev, Victor P3
  • Liu, Gang3
  • Weinfurt, Kevin9
  • Amundsen, Cindy L7
  • Bradley, Catherine S10
  • Kusek, John W11
  • Kirkali, Ziya11
  • 1 Michigan Medicine Urology Clinic, University of Michigan, Ann Arbor, Michigan. Electronic address: [email protected]
  • 2 Northwestern University Feinberg School of Medicine, Chicago, Illinois.
  • 3 Arbor Research Collaborative for Health, Ann Arbor, Michigan.
  • 4 NorthShore University HealthSystem, Glenview, Illinois.
  • 5 Urology Clinic, University of Washington Medical Center, Seattle, Washington.
  • 6 Michigan Medicine Urology Clinic, University of Michigan, Ann Arbor, Michigan.
  • 7 Division of Urogynecology and Reconstructive Surgery, Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina.
  • 8 Washington University School of Medicine in St. Louis, St. Louis, Missouri.
  • 9 Duke University Medical Center, Durham, North Carolina.
  • 10 Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, Iowa.
  • 11 National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland.
Published Article
The Journal of urology
Publication Date
Apr 01, 2018
DOI: 10.1016/j.juro.2017.10.035
PMID: 29111381


We described and compared the frequency and type of lower urinary tract symptoms reported by men and women at the time that they were recruited from urology and urogynecology clinics into the Symptoms of Lower Urinary Tract Dysfunction Research Network multicenter, prospective, observational cohort study. At 6 research sites treatment seeking men and women were enrolled who reported any lower urinary tract symptoms at a frequency more than rarely during the last month on the LUTS (Lower Urinary Tract Symptoms) Tool. At baseline the study participants underwent a standardized clinical evaluation and completed validated questionnaires. Urological tests were performed, including pelvic/rectal examination, post-void residual urine measurement and urinalysis. A total of 545 women and 519 men were enrolled in the study. Mean ± SD age was 58.8 ± 14.1 years. At baseline nocturia, frequency and a sensation of incomplete emptying were similar in men and women but men experienced more voiding symptoms (90% vs 85%, p = 0.007) and women reported more urgency (85% vs 66%, p <0.001). Women also reported more of any type of urinary incontinence than men (82% vs 51% p <0.001), which was mixed incontinence in 57%. Only 1% of men reported stress incontinence but they had other urinary incontinence, including post-void dribbling in 44% and urgency incontinence in 46%. Older participants had higher odds of reporting symptoms of nocturia and urgency. In this large, treatment seeking cohort of men and women lower urinary tract symptoms varied widely by gender and age. Men reported more voiding symptoms and nonstress or urgency urinary incontinence while women reported more incontinence overall and urgency. Older participants had greater odds of urgency and nocturia. Copyright © 2018 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

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