Affordable Access

deepdyve-link
Publisher Website

Baseline Characteristics and Treatment Patterns of the Patients Recruited to the China Registry of Hepatitis B.

Authors
  • Shan, Shan1
  • You, Hong1
  • Niu, Junqi2
  • Shang, Jia3
  • Xie, Wen4
  • Zhang, Yuexin5
  • Li, Xun6
  • Ren, Hong7
  • Tang, Hong8
  • Ding, Huiguo9
  • Wang, Xihong10
  • Nan, Yuemin11
  • Dou, Xiaoguang12
  • Han, Tao13
  • Zhang, Lingyi14
  • Liu, Xiaoqing15
  • Deng, Cunliang16
  • Cheng, Jilin17
  • Wang, Xiaozhong18
  • Xie, Qing19
  • And 33 more
  • 1 Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center for Digestive Diseases, Beijing, China. , (China)
  • 2 Department of Hepatology, First Hospital of Jilin University, Changchun, Jilin, China. , (China)
  • 3 Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou, Henan, China. , (China)
  • 4 Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. , (China)
  • 5 Department of Infectious Diseases, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China. , (China)
  • 6 Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, Gansu, China. , (China)
  • 7 Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. , (China)
  • 8 Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, Sichuan, China. , (China)
  • 9 Department of Gastroenterology and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing, China. , (China)
  • 10 Center of Infectious Diseases, The Third People's Hospital of Taiyuan, Taiyuan, Shanxi, China. , (China)
  • 11 Department of Traditional and Western Medical Hepatology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. , (China)
  • 12 Department of Infectious Diseases, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China. , (China)
  • 13 Department of Hepatology, Tianjin Third Central Hospital, Tianjin Medical University, Tianjin, China. , (China)
  • 14 Department of Hepatology, Lanzhou University Second Hospital, Lanzhou, Gansu, China. , (China)
  • 15 Department of Infectious Diseases, Peking Union Medical College Hospital, Beijing, China. , (China)
  • 16 Department of Infectious Diseases, The Affiliated Hospital of Southwest Medical University, Luzhou, Gansu, China. , (China)
  • 17 Department of Gastroenterology, Shanghai Public Health Clinical Center, Shanghai, China. , (China)
  • 18 Department of Hepatology, Xinjiang Uygur Autonomous Region Traditional Chinese Medicine Hospital, Urumqi, Xinjiang, China. , (China)
  • 19 Department of Infectious Diseases, Shanghai Ruijin Hospital, Jiao Tong University School of Medicine, Shanghai, China. , (China)
  • 20 Department of Infectious Diseases, The First Affiliated Hospital of Xian Jiao Tong University, Xi'an, Shaanxi, China. , (China)
  • 21 Department of Infectious Diseases, Xiangya Hospital Central South University, Changsha, Hunan, China. , (China)
  • 22 Department of Digestive System, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. , (China)
  • 23 Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China. , (China)
  • 24 Department of Infectious Diseases, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. , (China)
  • 25 Department of Infectious Diseases, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Henan, China. , (China)
  • 26 Department of Infectious Diseases, Yanbian University Hospital, Yanji, Jilin, China. , (China)
  • 27 Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. , (China)
  • 28 Department of Hepatology, The Fourth People's Hospital of Qinghai Province, Xining, Qinghai, China. , (China)
  • 29 Department of Infectious Diseases, Xinjiang Changji Prefecture People's Hospital, Changji, Xinjiang, China. , (China)
  • 30 Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China. , (China)
  • 31 Department of Hepatology, Hunan Provincial People's Hospital, Changsha, Hunan, China. , (China)
  • 32 Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. , (China)
  • 33 Department of Hepatology, Xixi Hospital of Hangzhou, Hangzhou, Zhejiang, China. , (China)
  • 34 Department of Infectious Diseases, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China. , (China)
  • 35 Department of Infectious Diseases, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei, China. , (China)
  • 36 Department of Hepatopancreatobiliary and Splenic Medicine, The Affiliated Hospital, Logistics University of People's Armed Police Force, Tianjin, China. , (China)
  • 37 Department of Infectious Diseases, Infectious Disease Hospital of Wuhai, Wuhai, Inner Mongolia, China. , (China)
  • 38 Department of Infectious Diseases, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China. , (China)
  • 39 Department of Infectious Diseases, The First Affiliated Hospital of Shanxi Medical University, Taiyuan, Shanxi, China. , (China)
  • 40 Department of Infectious Diseases, The Fifth Hospital of Shijiazhuang, Shijiazhuang, Hebei, China. , (China)
  • 41 Department of Infectious Diseases, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China. , (China)
  • 42 Department of Infectious Diseases, Hainan General Hospital, Haikou, Hainan, China. , (China)
  • 43 Department of Infectious Diseases, The Second Hospital of Shandong University, Jinan, Shandong, China. , (China)
  • 44 Department of Infectious Diseases, Yanan University Affiliated Hospital, Yan'an, Shaanxi, China. , (China)
  • 45 Department of Infectious Diseases, Peking University First Hospital, Beijing, China. , (China)
  • 46 Peking University Hepatology Institute, Peking University People's Hospital, Beijing, China. , (China)
  • 47 Institute of Hepatology and Department of Infectious Disease, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. , (China)
  • 48 Artificial Liver Center, Beijing Youan Hospital, Capital Medical University, Beijing, China. , (China)
  • 49 Department of Microbiology and Infectious Disease Center, Peking University Health Science Center, Beijing, China. , (China)
  • 50 The China Foundation of Hepatitis Prevention and Control, Beijing China. , (China)
  • 51 Center for Clinical Epidemiology and EBM, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing, China. , (China)
Type
Published Article
Journal
Journal of clinical and translational hepatology
Publication Date
Dec 28, 2019
Volume
7
Issue
4
Pages
322–328
Identifiers
DOI: 10.14218/JCTH.2019.00052
PMID: 31915601
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Background and Aims: Chronic hepatitis B virus (HBV) infection remains a major public health problem globally. Here, we describe the baseline characteristics and treatment profiles of HBV-infected patients recruited to the China Registry of Hepatitis B. Methods: Inclusion criteria were patients with different stages of chronic HBV infection and complete key data. Exclusion criteria were patients with hepatocellular carcinoma. The baseline clinical, laboratory and treatment profiles were analyzed. Results: Finally, 40,431 patients were included. The median age was 43 years, with 65.2% being men and 51.3% being positive for hepatitis B e antigen (HBeAg). The most common initial diagnosis was chronic hepatitis B (81.0%), followed by cirrhosis (9.3%), inactive carrier of hepatitis B surface antigen (HBsAg) (6.7%), and immune tolerant phase of hepatitis B infection (3.0%). Among the 21,228 patients who were on treatment, 88.0%, 10.0% and 2.0% received nucleos(t)ide analogues (NAs), interferon or combination of NAs and interferon, respectively. The proportion of patients who received preferred NAs (entecavir or tenofovir disoproxil fumarate) had increased from 13.5% in 2003 to 79.7% in 2016. Conclusions: We concluded that middle-aged men accounted for most of the patients with chronic hepatitis B in this cross-sectional study. About half of the patients were HBeAg-positive. NAs were the most commonly used therapy, and use of the preferred NAs had steadily increased in the past decade. © 2019 Authors.

Report this publication

Statistics

Seen <100 times