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Banking feces: a new frontier for public blood banks?

Authors
  • Jørgensen, Simon Mark Dahl1
  • Hvas, Christian Lodberg1
  • Dahlerup, Jens Frederik1
  • Mikkelsen, Susan2
  • Ehlers, Lars3
  • Hammeken, Lianna Hede3
  • Licht, Tine Rask4
  • Bahl, Martin Iain4
  • Erikstrup, Christian2
  • 1 Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark. , (Denmark)
  • 2 Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark. , (Denmark)
  • 3 Department of Business and Management, Danish Centre for Healthcare Improvements, Aalborg University, Aalborg, Denmark. , (Denmark)
  • 4 National Food Institute, Technical University of Denmark, Kgs. Lyngby, Denmark. , (Denmark)
Type
Published Article
Journal
Transfusion
Publication Date
Sep 01, 2019
Volume
59
Issue
9
Pages
2776–2782
Identifiers
DOI: 10.1111/trf.15422
PMID: 31241182
Source
Medline
Language
English
License
Unknown

Abstract

Fecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridioides difficile infection and is potentially beneficial in other microbiota-related disorders. The provision of FMT in routine clinical practice requires an extensive infrastructure that is reliant on voluntary donors. Alongside an increasing demand for FMT, the logistic barriers of a large-scale donor-dependent operation and the difficulties among health authorities to regulate FMT limit the dissemination of sustainable FMT services. Blood centers are large organizations that handle a multitude of donor-dependent operations on a daily basis. Blood and feces share many of the same dependencies, and feces may present a new opportunity for the blood services to handle. In this paper, we describe how an FMT service may be established and embedded within the blood service infrastructure, and we explain the benefits of using blood donors as feces donors. We further explore the current indications of FMT, the challenges related to the lack of legislation, and the future perspectives for blood banks to meet a new and increasing demand. © 2019 The Authors. Transfusion published by Wiley Periodicals, Inc. on behalf of AABB.

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