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Balgacyclamides, antiplasmodial heterocyclic peptides from Microcystis aeruguinosa EAWAG 251.

Authors
  • Portmann, Cyril
  • Sieber, Simon
  • Wirthensohn, Silvan
  • Blom, Judith F
  • Da Silva, Laeticia
  • Baudat, Emilie
  • Kaiser, Marcel
  • Brun, Reto
  • Gademann, Karl
Type
Published Article
Journal
Journal of Natural Products
Publisher
American Chemical Society
Publication Date
Mar 28, 2014
Volume
77
Issue
3
Pages
557–562
Identifiers
DOI: 10.1021/np400814w
PMID: 24392715
Source
Medline
License
Unknown

Abstract

The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A-C, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determined by 2D-NMR methods and mass spectrometry, and the configurations were assigned after ozonolysis and hydrolysis by HPLC-MS methods using Marfey's method as well as GC-MS using authentic standards. Balgacyclamides A and B were active against Plasmodium falciparum K1 in the low micromolar range, while displaying low toxicity to rat myoblasts.

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