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Balance on the Brain: a randomised controlled trial evaluating the effect of a multimodal exercise programme on physical performance, falls, quality of life and cognition for people with mild cognitive impairment-study protocol.

Authors
  • Burton, Elissa1, 2
  • Hill, Keith3
  • Ellis, Kathryn A4, 5
  • Hill, Anne-Marie6
  • Lowry, Meggen7
  • Moorin, Rachael8, 9
  • McVeigh, Joanne A10, 11
  • Jacques, Angela10, 12
  • Erickson, Kirk I13, 14, 15, 16
  • Tate, Joel17
  • Bernard, Sarah10, 18
  • Orr, Carolyn F19
  • Bongiascia, Luke20
  • Clarnette, Roger21
  • Clark, Melanie L22
  • Williams, Shannon23
  • Lautenschlager, Nicola24, 25
  • 1 Curtin School of Allied Health, Curtin University-Perth City Campus, Perth, Western Australia, Australia [email protected] , (Australia)
  • 2 enAble Institute, Curtin University, Perth, Western Australia, Australia. , (Australia)
  • 3 Rehabilitation, Ageing and Independent Living (RAIL) Research Centre, School of Primary and Allied Health Care, Monash University, Clayton, Victoria, Australia. , (Australia)
  • 4 The Academic Unit for Psychiatry of Old Age, Department of Psychiatry, University of Melbourne, Melbourne, Victoria, Australia. , (Australia)
  • 5 Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia. , (Australia)
  • 6 School of Allied Health, Western Australian Centre for Health and Ageing, The University of Western Australia, Perth, Western Australia, Australia. , (Australia)
  • 7 Next Step Health, Brisbane, Queensland, Australia. , (Australia)
  • 8 Curtin School of Population Health, Curtin University, Perth, Western Australia, Australia. , (Australia)
  • 9 School of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia. , (Australia)
  • 10 Curtin School of Allied Health, Curtin University, Perth, Western Australia, Australia. , (Australia)
  • 11 School of Physiology, University of Witwatersrand, Johannesburg, South Africa. , (South Africa)
  • 12 Institute for Health Research, University of Notre Dame Australia, Fremantle, Western Australia, Australia. , (Australia)
  • 13 Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • 14 College of Science, Health, Engineering, and Education, Murdoch University, Perth, Western Australia, Australia. , (Australia)
  • 15 Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • 16 PROFITH "PROmoting FITness and Health Through Physical Activity" Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain. , (Spain)
  • 17 Department of Rehabilitation and Aged Care, Armadale Health Service, Armadale, Western Australia, Australia. , (Australia)
  • 18 Geriatric Acute and Rehabilitation Medicine, Sir Charles Gairdner Hospital Group, Perth, Western Australia, Australia. , (Australia)
  • 19 Cognitive Clinic, Royal Perth Hospital, Perth, Western Australia, Australia. , (Australia)
  • 20 Physiotherapy Department, Adult Community and Allied Health Directorate, Rockingham Peel Group, Rockingham, Western Australia, Australia. , (Australia)
  • 21 Medical School, University of Western Australia, Perth, Western Australia, Australia. , (Australia)
  • 22 Neurosciences Unit, North Metropolitan Health Service Mental Health, Public Health and Dental Services, Perth, Western Australia, Australia. , (Australia)
  • 23 Neurogenetic Clinic and Physiotherapy Department, Royal Perth Hospital, Perth, Western Australia, Australia. , (Australia)
  • 24 Academic Unit of Psychiatry of Old Age, University of Melbourne, Melbourne, Victoria, Australia. , (Australia)
  • 25 NorthWestern Mental Health, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. , (Australia)
Type
Published Article
Journal
BMJ Open
Publisher
BMJ
Publication Date
Apr 18, 2022
Volume
12
Issue
4
Identifiers
DOI: 10.1136/bmjopen-2021-054725
PMID: 35437246
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Exercise and physical activity have been shown to improve cognition for people living with mild cognitive impairment (MCI). There is strong evidence for the benefits of aerobic exercise and medium evidence for participating in regular strength training for people with MCI. However, people living with MCI fall two times as often as those without cognitive impairment and the evidence is currently unknown as to whether balance training for people with MCI is beneficial, as has been demonstrated for older people without cognitive impairment. The aim of this study is to determine whether a balance-focused multimodal exercise intervention improves balance and reduces falls for people with MCI, compared with a control group receiving usual care. This single blind randomised controlled trial (Balance on the Brain) will be offered to 396 people with MCI living in the community. The multimodal exercise intervention consists of two balance programmes and a walking programme to be delivered by physiotherapists over a 6-month intervention period. All participants will be followed up over 12 months (for the intervention group, this involves 6-month intervention and 6-month maintenance). The primary outcomes are (1) balance performance and (2) rate of falls. Physical performance, levels of physical activity and sedentary behaviour, quality of life and cognition are secondary outcomes. A health economic analysis will be undertaken to evaluate the cost-effectiveness of the intervention compared with usual care. Ethics approval has been received from the South Metropolitan Health Service Human Research Ethics Committee (HREC), Curtin University HREC and the Western Australia Department of Health HREC; and approval has been received to obtain data for health costings from Services Australia. The results will be disseminated through peer-review publications, conference presentations and online platforms. ACTRN12620001037998; Australian New Zealand Clinical Trials Registry (ANZCTR). © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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