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BacteRiophage EXclusion (BREX): A novel anti-phage mechanism in the arsenal of bacterial defense system.

Authors
  • Chaudhary, Kulbhushan1
  • 1 Division of Plant Pathology, Indian Agricultural Research Institute, Advanced Centre for Plant Virology, New Delhi, India. , (India)
Type
Published Article
Journal
Journal of Cellular Physiology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Feb 01, 2018
Volume
233
Issue
2
Pages
771–773
Identifiers
DOI: 10.1002/jcp.25973
PMID: 28444888
Source
Medline
Keywords
License
Unknown

Abstract

The arm race between bacteria and phages leads to the development of many phage resistance mechanisms. Bacteria are perpetually changing their strategy to avert phage infection and killing. Recently, a study published that shed light on a novel bacterial defense system called bacteriophage exclusion (BREX). BREX system is a six-gene cassette in Bacillus cereus which provides complete phage resistance to a broad range of phages, including lytic and temperate ones. It is a novel defense strategy which involves DNA methylation of the host cell and block phage DNA replication.

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