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Bactericidal antibody against a representative epidemiological meningococcal serogroup B panel confirms that MATS underestimates 4CMenB vaccine strain coverage.

Authors
  • Frosi, Giacomo1
  • Biolchi, Alessia
  • Lo Sapio, Morena
  • Rigat, Fabio
  • Gilchrist, Stefanie
  • Lucidarme, Jay
  • Findlow, Jamie
  • Borrow, Ray
  • Pizza, Mariagrazia
  • Giuliani, Marzia Monica
  • Medini, Duccio
  • 1 Research Center, Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy. Electronic address: [email protected] , (Italy)
Type
Published Article
Journal
Vaccine
Publication Date
Oct 09, 2013
Volume
31
Issue
43
Pages
4968–4974
Identifiers
DOI: 10.1016/j.vaccine.2013.08.006
PMID: 23954380
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

4CMenB (Bexsero), a vaccine developed against invasive meningococcal disease caused by capsular group B strains (MenB), was recently licensed for use by the European Medicines Agency. Assessment of 4CMenB strain coverage in specific epidemiologic settings is of primary importance to predict vaccination impact on the burden of disease. The Meningococcal Antigen Typing System (MATS) was developed to predict 4CMenB strain coverage, using serum bactericidal antibody assay with human complement (hSBA) data from a diverse panel of strains not representative of any specific epidemiology. To experimentally validate the accuracy of MATS-based predictions against strains representative of a specific epidemiologic setting. We used a stratified sampling method to identify a representative sample from all MenB disease isolates collected from England and Wales in 2007-2008, tested the strains in the hSBA assay with pooled sera from infant and adolescent vaccinees, and compared these results with MATS. MATS predictions and hSBA results were significantly associated (P=0.022). MATS predicted coverage of 70% (95% CI, 55-85%) was largely confirmed by 88% killing in the hSBA (95% CI, 72-95%). MATS had 78% accuracy and 96% positive predictive value against hSBA. MATS is a conservative predictor of strain coverage by the 4CMenB vaccine in infants and adolescents. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

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