Affordable Access

deepdyve-link
Publisher Website

Bactericidal activity of multiple combinations of tigecycline and colistin against NDM-1-producing Enterobacteriaceae.

Authors
  • Albur, Mahableshwar1
  • Noel, Alan
  • Bowker, Karen
  • MacGowan, Alasdair
  • 1 Bristol Centre for Antimicrobial Research and Evaluation, Department of Medical Microbiology, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol, United Kingdom. [email protected] , (United Kingdom)
Type
Published Article
Journal
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Publication Date
Jun 01, 2012
Volume
56
Issue
6
Pages
3441–3443
Identifiers
DOI: 10.1128/AAC.05682-11
PMID: 22391543
Source
Medline
License
Unknown

Abstract

The interaction between colistin and tigecycline against eight well-characterized NDM-1-producing Enterobacteriaceae strains was studied. Time-kill methodology was employed using a 4-by-4 exposure matrix with pharmacokinetically achievable free drug peak, trough, and average 24-h serum concentrations. Colistin sulfate and methanesulfonate alone showed good early bactericidal activity, often with subsequent regrowth. Tigecycline alone had poor activity. Addition of tigecycline to colistin does not produce increased bacterial killing; instead, it may cause antagonism at lower concentrations.

Report this publication

Statistics

Seen <100 times