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Bactericidal activity of hexylresorcinol lozenges against oropharyngeal organisms associated with acute sore throat

Authors
  • Matthews, Derek1
  • Adegoke, Oluwajoba2
  • Shephard, Adrian1
  • 1 Reckitt Benckiser Healthcare International Ltd, 103–105 Bath Road, Slough, Berkshire, SL1 3UH, UK , Slough, Berkshire (United Kingdom)
  • 2 Reckitt Benckiser Healthcare UK Ltd, Dansom Lane, Hull, HU8 7DS, UK , Hull (United Kingdom)
Type
Published Article
Journal
BMC Research Notes
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Feb 24, 2020
Volume
13
Issue
1
Identifiers
DOI: 10.1186/s13104-020-04954-1
Source
Springer Nature
Keywords
License
Green

Abstract

ObjectiveFor the majority of people with acute sore throat, over-the-counter treatments represent the primary option for symptomatic relief. This study evaluated the in vitro bactericidal activity of lozenges containing the antiseptic hexylresorcinol against five bacteria associated with acute sore throat: Staphylococcus aureus, Streptococcus pyogenes, Moraxella catarrhalis, Haemophilus influenzae and Fusobacterium necrophorum.ResultsHexylresorcinol 2.4 mg lozenges were dissolved into 5 mL of artificial saliva medium. Inoculum cultures were prepared in triplicate for each test organism to give an approximate population of 108 colony-forming units (cfu)/mL. Bactericidal activity was measured by log reduction in cfu. Greater than 3log10 reductions in cfu were observed at 1 min after dissolved hexylresorcinol lozenges were added to S. aureus (log10 reduction cfu/mL ± standard deviation, 3.3 ± 0.2), M. catarrhalis (4.7 ± 0.4), H. influenzae (5.8 ± 0.4) and F. necrophorum (4.5 ± 0.2) and by 5 min for S. pyogenes (4.3 ± 0.4). Hexylresorcinol lozenges achieved a > 99.9% reduction in cfu against all tested organisms within 5 min, which is consistent with the duration for a lozenge to dissolve in the mouth. In conclusion, in vitro data indicate that hexylresorcinol lozenges offer rapid bactericidal activity against organisms implicated in acute sore throat.

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