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Bacterial proteases from the intracellular vacuole niche; protease conservation and adaptation for pathogenic advantage.

Authors
  • Huston, Wilhelmina M
Type
Published Article
Journal
FEMS Immunology & Medical Microbiology
Publisher
Oxford University Press
Publication Date
Jun 01, 2010
Volume
59
Issue
1
Pages
1–10
Identifiers
DOI: 10.1111/j.1574-695X.2010.00672.x
PMID: 20402770
Source
Medline
License
Unknown

Abstract

Proteases with important roles for bacterial pathogens that specifically reside within intracellular vacuoles are frequently homologous to those that have important virulence functions for other bacteria. Research has identified that some of these conserved proteases have evolved specialized functions for intracellular vacuole-residing bacteria. Unique proteases with pathogenic functions have also been described from Chlamydia, Mycobacteria, and Legionella. These findings suggest that there are further novel functions for proteases from these bacteria that remain to be described. This review summarizes the recent findings of novel protease functions from the intracellular human pathogenic bacteria that reside exclusively in vacuoles.

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