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BACE1 activity regulates cell surface contactin-2 levels.

Authors
  • Gautam, Vivek
  • D'Avanzo, Carla
  • Hebisch, Matthias
  • Kovacs, Dora M
  • Kim, Doo Yeon
Type
Published Article
Journal
Molecular Neurodegeneration
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Jan 01, 2014
Volume
9
Pages
4–4
Identifiers
DOI: 10.1186/1750-1326-9-4
PMID: 24405708
Source
Medline
License
Unknown

Abstract

Our results clearly demonstrate that mouse and human contactin-2 are physiological substrates for BACE1. BACE1-mediated contactin-2 cleavage tightly regulates the surface expression of contactin-2 in neuronal cells. Given the role of contactin-2 in cell adhesion, neurite outgrowth and axon guidance, our data suggest that BACE1 may play an important role in these physiological processes by regulating contactin-2 surface levels.

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