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Altered Signal Transduction in Carcinogenesis1

Elsevier B.V.
DOI: 10.1016/s1569-2558(08)60235-0
  • Biology
  • Ecology
  • Geography


Publisher Summary To illustrate the usefulness of altered signal transduction as a conceptual framework for the molecular events associated with carcinogenesis, this chapter focuses on altered signal transduction in colon cancer and in the multidrug resistance (MDR) phenotype of tumor cells that is at least in part responsible for the intrinsic drug resistance commonly observed in colon cancer. The chapter discusses the altered expression of protein kinase C (PKC) activity in colon carcinogenesis and the altered regulation of PKC activity by environmental factors that influence the development of colon cancer. It also discusses the oncogene activation and tumor suppressor gene inactivation: critical events in human colon carcinogenesis. The role of altered signal transduction in the intrinsic drug resistance of human colon cancer and tumor antigen transport and the multidrug resistance (MDR) phenotype-α hypothesis are also discussed in the chapter.

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