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Baccharis dracunculifolia DC (Asteraceae) selectively modulates the effector functions of human neutrophils.

Authors
  • Figueiredo-Rinhel, Andréa S G1
  • de Melo, Lamartine L1, 2
  • Bortot, Leandro O1
  • Santos, Everton O L1, 2
  • Andrade, Micássio F1, 2
  • Azzolini, Ana Elisa C S1
  • Kabeya, Luciana M1
  • Caliri, Antonio1
  • Bastos, Jairo K3
  • Lucisano-Valim, Yara Maria1
  • 1 Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, SP, Brazil. , (Brazil)
  • 2 Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, SP, Brazil. , (Brazil)
  • 3 Departamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, SP, Brazil. , (Brazil)
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Dec 01, 2017
Volume
69
Issue
12
Pages
1829–1845
Identifiers
DOI: 10.1111/jphp.12822
PMID: 28994118
Source
Medline
Keywords
License
Unknown

Abstract

BdE selectively modulates the effector functions of human neutrophils, inhibits the activity of key enzymes and scavenges physiological oxidant species. Caffeic acid contributes to lower the levels of oxidant species. Our findings help to unravel the mechanisms by which these natural products exert immunomodulatory action towards neutrophils.

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