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Influence of Ca2+on synaptic morphology of fish cone photoreceptors

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
546
Issue
2
Identifiers
DOI: 10.1016/0006-8993(91)91499-q
Keywords
  • Photoreceptor
  • Cone
  • Synapse
  • Exocytosis
  • Ca2+

Abstract

Abstract Isolated fish retinas were incubated with the Ca 2+-ionophore A23187 at various Ca 2+ concentrations. Computer reconstructions of the ultrastructure of cone synapses revealed pronounced reduction of the presynaptic surface (complete loss of the synaptic invaginations) in response to low intracellular Ca 2+ (<10 −8M). No obvious effect on synaptic morphology was noticed at Ca 2+ greater than 10 −8 M. Ca 2+-dependent exocytotic activity appears to be a major factor controlling the invaginated morphology of cone synapses.

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