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N-Phenoxyacetylated guanosine and adenosine phosphoramidites in the solid phase synthesis of oligoribonucleotides: Synthesis of a ribozyme sequence

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
29
Issue
34
Identifiers
DOI: 10.1016/s0040-4039(00)80466-9

Abstract

Abstract Phosphoramidites for guanosine and adenosine nucleosides with phenoxyacetyl as N-acyl protecting group were prepared. These nucleoside phosphoramidites, together with previously reported uridine and N-benzoyl cytidine phosphoramidites have been applied to the efficient solid phase synthesis of a trideca and a nonadecaribonucleotide. The later molecule has the sequence corresponding to a ribozyme.

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