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Design and synthesis of calix[4]arene–nucleoside hybrids

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
43
Issue
36
Identifiers
DOI: 10.1016/s0040-4039(02)01372-2

Abstract

Abstract Synthesis of calixnucleosides (hybrid molecules between calix[4]arenes and nucleosides) has been achieved by amide bond formation between amine functional groups of para-1,3-diaminocalix[4]arene and carboxylic acid groups of thymidine nucleosides. Three types of calixnucleosides were efficiently prepared and X-ray crystallography of a homocoupled calixnucleoside revealed an interesting hydrogen-bonding pattern between thymine bases and the amide linkages.

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