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Preparation of the enantiomers of 19-epoxy docosahexaenoic acids and their 4-hydroxy derivatives

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
11
Issue
4
Identifiers
DOI: 10.1016/s0957-4166(00)00015-x
Disciplines
  • Biology

Abstract

Abstract By the action of NBS in aq. DME, dl-19-bromo-20-hydroxy-DHA methyl ester 5 was prepared, which was effectively resolved by lipase PS and vinyl acetate in the presence of a thiacrown ether to give 7 and 8, each being transformed into the corresponding epoxides, 1 and 2, respectively. The absolute configuration of 8 was established by the Kusumi–Moscher method. For the purpose of biological evaluation, both epoxides were converted to the γ-lactones 3 and their 4-hydroxy derivatives 4.

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