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Absence of paired cisternae during mitosis in the presence of actinomycin D and puromycin

Authors
Journal
Journal of Ultrastructure Research
0022-5320
Publisher
Elsevier
Publication Date
Volume
40
Identifiers
DOI: 10.1016/s0022-5320(72)90104-9

Abstract

In vitro tumor cells from rats with 90Sr-induced leukemia were observed to possess elaborate membranous lamellae in the perinuclear cytoplasm during mitosis. These “stacked remnants of nuclear envelope” were absent, however, after cultures were treated with nonlethal doses of either actinomycin D or puromycin. It is concluded that paired cisternae present in mitosis are products of prior synthesis, not remnants of nuclear envelope dispersed during late prophase. A possible contribution to Golgi centers, endoplasmic reticulum, and restoration of the nuclear envelope during telophase is discussed.

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