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The use of immunologically competent cells in the treatment of cancer. Further experiments with a transplantable mouse tumour.

Authors
Journal
British Journal of Cancer
0007-0920
Publisher
Nature Publishing Group
Publication Date
Keywords
  • Research Article
Disciplines
  • Design
  • Medicine

Abstract

178 THE USE OF IMMUNOLOGICALLY COMPETENT CELLS IN THE TREATMENT OF CANCER FURTHER EXPERIMENTS WITH A TRANSPLANTABLE MOUSE TUMOUR M. 0. SYMES From the Department of Surgery, Uniiersity of Bristol, Bristol Royal Infirmary Received for publication November 8, 1966 WOODRUFF and Symes (1962a) reported that the growth of subcutaneous mouse mammary carcinoma transplants, in isogenic hosts, could be retarded by the administration of sub-lethal whole body irradiation followed by intravenous injection of allogeneic immunologically competent cells. Destruction of the tumour, however, could only be achieved at the expense of killing the host through the effects of concomitant graft-versus-host disease. It therefore seemed desirable to seek methods whereby the graft-versus-host reaction could be reduced whilst retaining or increasing the graft-versus-tumour effect. With this in mind, Woodruff, Symes and Boak (unpublished) repeated the experiments cited above with the difference that allogeneic cells were injected intraperitoneally in the treatment of intraperitoneal tumour transplants. The result of this immediate intimate contact between the donor spleen and tumour cells was a significant prolongation of host survival with minimal graft-versus-host disease; however, no animals were " cured ". An alternative approach designed to elucidate the cell type responsible for the anti-tumour effect was that of Woodruff, Symes and Stuart (1963) and Wood- ruff, Symes and Anderson (1963), who treated mice bearing transplants of the genetically nonspecific Landschutz ascites tumour by intraperitoneal injection of either spleen cells or thoracic duct lymphocytes from rats of an inbred strain, previously immunized against the tumour. The therapeutic superiority of the duct lymphocytes was clearly demonstrated. The evidence that an immunological reaction was involved in the anti-tumour effect may be summarized thus: (i) The effect of immunologically competent cells from donors previously immunized against the t

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