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Fumaric acid esters in dermatology

Authors
Journal
Indian Dermatology Online Journal
2229-5178
Publisher
Medknow Publications
Publication Date
Volume
2
Issue
2
Identifiers
DOI: 10.4103/2229-5178.86007
Keywords
  • Drug Profile
Disciplines
  • Medicine

Abstract

Fumaric acid esters (FAE) are substances of interest in dermatology. FAE exert various activities on cutaneous cells and cytokine networks. So far only a mixture of dimethylfumarate (DMF) and three salts of monoethylfumarate (MEF) have gained approval for the oral treatment of moderate-to-severe plaque-type psoriasis in Germany. DMF seems to be the major active component. There is evidence that FAE are not only effective and safe in psoriasis but granulomatous non-infectious diseases like granuloma annulare, necrobiosis lipoidica and sarcoidosis. In vitro and animal studies suggest some activity in malignant melanoma as well.

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