Abstract ( Simultaneous determination of trace elements in high-purity chromium by inductively-coupled plasma/atomic emission spectrometry after matrix separation.) The production of high-purity metals requires routine determinations of elements in the ng g −1 range. Procedures based on wet chemical separation of matrix and trace elements followed by inductively-coupled plasma/atomic emission spectrometry are suitable. The separation of 19 trace metals (Be, Bi, Ca, Cd, Co, Cu, Fe, La, Mg, Mn, Nb, Ni, Pb, Ta, Ti, Th, U, Zn and Zr) from high-purity chromium powder is described. The powder is dissolved in hydrochloric acid and oxidized with perchloric acid or alkaline hydrogen peroxide, and the trace elements are precipitated at pH 11–13 and collected on cellulose loaded with indium hydroxide or on cellulose-Hyphan. The detection limits of the total procedure vary from 10 ng g −1 for cadmium to 600 ng g −1 for zinc.