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Mechanism of water transport in controlled porosity osmotic devices

Authors
Journal
Journal of Membrane Science
0376-7388
Publisher
Elsevier
Publication Date
Volume
40
Issue
3
Identifiers
DOI: 10.1016/s0376-7388(00)81152-7

Abstract

Abstract Controlled drug delivery devices that release the drug from an osmotic core by a pumping mechanism are promising for the oral administration of water-soluble drugs. This study considers various possible paths for the transport of water through a porous cellulose acetate membrane which constitutes the outer wall of a particular osmotic device. It is shown that the mechanism of water transport is not solely by diffusion through the semipermeable cellulose acetate or water-filled voids: solute-excluding water-filled regions in the coat as well as the polymeric portion of the coat are important in water ingress into the osmotic pump.

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