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Synthesis of isoxazolidin-5-ones via stereocontrolled Michael additions of benzylhydroxylamine tol-serine derived α,β-unsaturated esters

Authors
Journal
Tetrahedron Asymmetry
0957-4166
Publisher
Elsevier
Publication Date
Volume
9
Issue
22
Identifiers
DOI: 10.1016/s0957-4166(98)00412-1
Keywords
  • Communication

Abstract

Abstract The synthesis of optically active isoxazolidin-5-ones from α,β-unsaturated esters is reported. The key features of this synthetic sequence include the stereocontrolled Michael addition of benzylhydroxylamine to alkenes 7 and 8 and the intramolecular cyclization to the target compounds

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