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Some aspects of phospholipid metabolism in the red cell

Authors
Journal
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
0005-2760
Publisher
Elsevier
Publication Date
Volume
144
Issue
2
Identifiers
DOI: 10.1016/0005-2760(67)90168-3
Disciplines
  • Biology

Abstract

Abstract 1. (1) Long-chain carnitine acyl transferase activity in red cell membranes was demonstrated by their capacity to incorporate [1- 14C]oleic acid and [1- 14C]linoleic acid into the respective acylcarnitines. The addition of (−)-carnitine to red cell membranes enhanced [1- 14C]palmitate incorporation into palmitylcarnitine, whereas (+)-carnitine was without effect. (+)-Palmitylcarnitine resulted in a depression of [1- 14C]palmitate incorporation into palmitylcarnitine, and this inhibition was reversed by the addition of (−)-carnitine. 2. (2) Fatty acylcarnitine derivatives were shown not to be obligatory intermediates in the incorporation of fatty acyi CoA into lecithin, and the addition of (−)-carnitine increased incorporation of [1- 14C]palmitate into palmitylcarnitine while decreasing incorporation of [1- 14C]palmitate into lecithin. 3. (3) ‘Methyltransferase’ activity was demonstrated in human and sheep erythrocytes. Significant incorporation into lecithin, sphingomyelin, methylated phosphatidylethanolamine derivatives and lysolecithin was found with S-[ Me- 14C]adenosylmethionine. Methionine-activating enzyme activity was absent.

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