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Survival after radiotherapy in gastric cancer: Systematic review and meta-analysis

Authors
Journal
Radiotherapy and Oncology
0167-8140
Publisher
Elsevier
Publication Date
Volume
92
Issue
2
Identifiers
DOI: 10.1016/j.radonc.2009.06.014
Keywords
  • Gastric Cancer
  • Radiotherapy
  • Meta-Analysis
  • Systematic Review
  • Randomized Clinical Trial
Disciplines
  • Medicine

Abstract

Abstract Background and purpose A systematic review and meta-analysis was performed to assess the impact of radiotherapy on both 3- and 5-year survival in patients with resectable gastric cancer. Methods Randomized Clinical Trials (RCTs) in which radiotherapy, (preoperative, postoperative and/or intraoperative), was compared with surgery alone or surgery plus chemotherapy in resectable gastric cancer were identified by searching web-based databases and supplemented by manual examination of reference lists. Meta-analysis was performed using Risk Ratios (RRs). Random or fixed effects models were used to combine data. The methodological quality was evaluated by Chalmers’ score. Results Radiotherapy had a significant impact on 5-year survival. Using an intent to treat (ITT) and a Per Protocol (PP) analysis, the overall 5-year RR was 1.26 (95% CI: 1.08–1.48; NNT = 17) and 1.31 (95% CI: 1.04–1.66; NNT = 13), respectively. Although the quality of the studies was variable, the data were consistent and no clear publication bias was found. Conclusion This meta-analysis showed a statistically significant 5-year survival benefit with the addition of radiotherapy in patients with resectable gastric cancer. Radiotherapy remains a standard component in the treatment of resectable gastric cancer and new RCTs need to address the impact of new conformal radiotherapy technologies.

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